Development of thermostable Streptokinase by recombinant DNA technology as fibrinolytic agent for different thromboembolic disorders
نویسندگان
چکیده
Edicine is a therapeutic agent in the management of thromboembolic blockade. Streptokinase presently utilized clinical mase and an extracellular protein secreted by certain strains beta-hemolytic streptococci. It activates plasminogen to produce plasmin, enzyme that breaks down fibrin clots through specific lysine binding sites.
منابع مشابه
fibrinolytic activity of recombinant mutant streptokinase
background: streptokinase is a bacterial protein produced by different beta hemolytic streptococci and widely used in thrombolytic treatment. the main disadvantage of using streptokinase is antibody formation which causes allergic reaction to neutralize effects of streptokinase therapy. aim of this study was investigate of recombinant mutant streptokinase fibrinolytic activity. m aterials and m...
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The systemic fibrinolytic activity of intrapleural streptokinase.
Intrapleural fibrinolytics probably improve the drainage of loculated pleural effusions and empyemas. Studies of crude indices of systemic coagulation suggest this effect is accompanied by little systemic fibrinolysis, but few studies have assessed this in detail. This study examines the systemic fibrinolytic activity of two intrapleural streptokinase (IPSK) regimes in detail. Eight patients re...
متن کاملPharmacology of fibrinolysis.
Fibrinolytic therapy has an expanding role in the treatment of many thromboembolic disorders. Four fibrinolytic drugs are currently marketed: streptokinase, anisoylated plasminogen-streptokinase activator complex, urokinase, and recombinant human tissue-type plasminogen activator. All 4 of these drugs activate the fibrinolytic system by converting plasminogen to the active enzyme, plasmin. Plas...
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ژورنال
عنوان ژورنال: Journal of Medical and Life Science (Print)
سال: 2022
ISSN: ['2636-4093', '2636-4107']
DOI: https://doi.org/10.21608/jmals.2022.288999